CPPPS50*

Polyethersulfone Membrane – PS

PS Capsules are hydrophilic and manufactured with the highest quality asymmetric polyethersulfone membrane. Polyethersulfone membrane exhibits excellent flow rates with precise retention ratings. PS capsules are used for the most critical applications including beverage, electronic and pharmaceutical. PS capsules can handle a wide range of pH and chemical compatibility. Many applications include high purity water, process water, wine, inks, dyes, acids, bases and oxidants. Used for solvents, cosmetics, alcohols and many others. Our double layered pharmaceutical PS capsules see broad service in sterile fill applications in SVPs and biological products. Polyethersulfone is particularly suited for the filtration of products whose constituents, such as preservatives, can adsorb to the media. The lower binding characteristics of Polyethersulfone make it a good choice for filtration of valuable protein solutions such as vaccines and other biologicals. PPS 0.22 micron membrane is sterilizing grade LAL tested, non-reactive. 100% integrity tested.

See the Flow Rate table in more image which represents typical water flow at a one psi (69 mbar) pressure differential across a single 2 inch capsule 1.0 ft² (930 cm²) of media with 1/2″ FNPT ports. The test fluid is water at ambient temperature. Higher pressure drops is acceptable, but as flows increase the pressure drop of the housing becomes more apparent.

The media utilized in these capsules is optimized for retention and durability to meet the extra security needs of the pharmaceutical industry. Each module is rinsed with 17+ megohm-cm water to remove potential extraneous manufacturing debris. Each cartridge module is individually tested for integrity. Further, representative cartridge modules have been validated to show equivalent retention characteristics per the deigned protocol.

P – grade capsules are validated using modified HIMA protocols at a challenge level of 10⁷ organisms per cm² of filter media.
F & E – grade capsules are validated using modified HIMA protocols at a challenge level of 10⁶ organisms per cm² of filter media.
G – grade capsules are validated using modified HIMA protocols at a challenge level of 10⁴ organisms per cm² of filter media.
(0.22 µm challenged with Brevundimonas diminuta) (0.45 µm challenged with Serratia marcescens) (0.65 µm challenged with Saccharomyces cerevisiae).

All materials of construction are FDA accepted. Final assemblies have been validated to pass USP class 6 Toxicology extractable tests, oxidizable substances for plastics, endotoxin level and other quality tests.

Industry standard concentrations of hydrogen peroxide, peracetic acid, sodium hypochlorite and other selected chemicals. Sanitization protocols designed to extend the useful life of CP capsules are available from Critical Process Filtration, Inc.®.

The materials used to construct the membrane capsule filters are non-toxic and meet the requirements for the MEM Elution Cytotoxicity Test and USP24 Plastic Class V1 121°C Test.

Our goal is to ensure our customers the greatest possible value for their filtration dollar. We achieve both low cost manufacture and high quality by employing state of the art manufacturing equipment. This computer controlled equipment is highly automated, reducing hand operations that compromise quality. Each operation including assembly, testing, cleaning, drying and packaging is done in appropriately rated clean rooms. Critical Process Filtration manages an ISO 9000 facility that produces validated products to rigorous standards. Manufacturing is controlled using sophisticated MRP software that is networked to work stations in manufacturing centers and inspection points. During the manufacturing and inspection processes, data is collected “real time” from machinery and measuring instruments. This allows variable and attribute data to be quickly and easily analyzed to facilitate constant improvements in both quality and cost.

Critical Process Filtration, Inc.® is a vertically integrated supplier of filtration products and services to industries in which filtration is considered to be a critical part of the manufacturing process. We manufacture a complete line of products to help you achieve all your filtration requirements from a single source.